WHY WE NEED YOU

We’re challenging Tradies all around Australia to help raise vital funds for game-changing research. By hosting a Tradie Tea Party, you will help us build towards a breast cancer breakthrough and stop breast cancer taking the ones we love.

Working towards zero deaths by 2030:

Our mission is simple: stop deaths from breast cancer.

How? By identifying, funding and championing world-class research - research that will help us detect tumours earlier, improve treatment outcomes, and ultimately – save lives.

Impact of your fundraising

Could support a world-class research team to uncover how factors such as location, demographics and socio-economic conditions impact survival outcomes.

Could support a world-class research team to develop a personalised vaccine that will boost the body’s own immune system to eradicate breast cancer cells.

Could support a world-class research team to develop better predictive tests that detect the presence of resistant cancer cells well before they start to grow as a secondary cancer.

What funding means to our researchers

We have a number of ground-breaking research projects focused on tackling the biggest hurdles to save lives from breast cancer. Here are two of our researchers… With your urgent support, we can fund more.

DR LIZ CALDON

Garvan Institute of Medical Research, NSW Project title: Discovering the mechanisms that cause anti-estrogen therapy resistance in breast cancer.

About 70% of all breast cancer types are estrogen receptor positive cancers that are treated with endocrine therapy. But a large number develop resistant to treatment and spread to other parts of the body. Metastatic recurrence in estrogen receptor positive disease is the biggest contributor to mortality in breast cancer.

But NBCF-funded researcher Dr Liz Caldon is determined to change that. Her research is focused in understanding the way that some breast cancer cells evolve and become more resilient to the effects of therapeutic drugs. Using state-of-the-art technology the genetic changes of cancer cells will be studied in model systems that capture the earliest changes that occur when breast cancer cells start to become resistant to treatment. The knowledge gained from this study will be used to design more effective therapies.

“NBCF has helped shape my research direction towards the discovery of mechanisms of drug resistance in breast cancer. They provided pivotal support at transition periods in my career when I have been establishing an independent research direction. The money you raise makes a big difference.”

PROFESSOR RICCARDO DOLCETTI

The University of Queensland, QLD Project title: Personalising immunotherapy for breast cancer.

A certain class of drugs that stimulate the immune system to attack cancer has shown promising results in previously untreatable cancers. However, at present, these drugs are only effective in a small number of breast cancers and may cause adverse immune reactions due to their lack of specificity. As such, there is a need to tailor tumour fighting immune responses.

To overcome these limitations, NBCF-funded Professor Riccardo Dolcetti has developed a method to identify the unique antigens expressed by each individual breast cancer that can be targeted with personalised immunotherapy – using parts of one’s immune system to target cancer. Ultimately, his works hope to lead to a clinically vaccine that boost the immune system to target the hardest to treat forms of breast cancer.

"The funds you raise give highly motivated researchers more time, tools and resources to work on developing life-saving treatments for breast cancer patients.”